Faculty Sponsor(s)
Cecilia Toro
Location
Jereld R. Nicholson Library: Grand Avenue
Subject Area
Biology
Description
πΎ-aminobutyric acid (GABA) is a neurotransmitter that has been shown to be present in the inner ear. GABA binds to two classes of GABA receptors (GABARs): GABAARs are pentameric ion channels (isoforms include: πΌ 1-6, Ξ² 1-3, πΎ 1-3, π 1-3, πΏ, π, and π); GABABRs are G-protein coupled receptors (isoforms include: 1a, 1b, and 2). Studies have shown that GABAAR and GABABR transcripts are located in the inner ear but their function is not yet fully understood. This is in part due to access to the inner ear being very limited. Our experiments are designed to further our understanding of the role of GABA in the inner ear by utilizing the lateral line of the zebrafish.
Recommended Citation
O'Keefe, Jack, "Determining the Location of GABA Receptor mRNA Transcripts in Danio rerio" (2018). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 65.
https://digitalcommons.linfield.edu/symposium/2018/all/65
Determining the Location of GABA Receptor mRNA Transcripts in Danio rerio
Jereld R. Nicholson Library: Grand Avenue
πΎ-aminobutyric acid (GABA) is a neurotransmitter that has been shown to be present in the inner ear. GABA binds to two classes of GABA receptors (GABARs): GABAARs are pentameric ion channels (isoforms include: πΌ 1-6, Ξ² 1-3, πΎ 1-3, π 1-3, πΏ, π, and π); GABABRs are G-protein coupled receptors (isoforms include: 1a, 1b, and 2). Studies have shown that GABAAR and GABABR transcripts are located in the inner ear but their function is not yet fully understood. This is in part due to access to the inner ear being very limited. Our experiments are designed to further our understanding of the role of GABA in the inner ear by utilizing the lateral line of the zebrafish.
