Faculty Sponsor(s)
Brian Gilbert
Subject Area
Chemistry
Description
Gold nanoparticles (GNPs) have proven to be versatile technological tools, especially in the field of biomedicine. GNPs can be functionalized through different coatings for tasks like drug delivery, diagnostics, and biosensing. To further understand how GNPs can be altered for use as a biomedical tool, the cellular association of GNPs coated in different combinations of polyethylene glycol (PEG), sodium citrate, bovine serum albumin (BSA), and rabbit anti Saccharomyces Cerevisiae (antibody) with yeast cells was evaluated. This was tested through two main sample groups coated in either a base layer of sodium citrate or PEG. Each group had three samples that were tested, one only including the base coating, one including the base and BSA, and another including the base, BSA, and the antibody. Each sample was incubated with yeast and then analyzed through the use of a Nanosight.
Recommended Citation
Greiner, Olivia A., "Analyzing the Association of Coated Gold Nanoparticles Utilizing Yeast Cells" (2026). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 5.
https://digitalcommons.linfield.edu/symposium/2026/all/5
Analyzing the Association of Coated Gold Nanoparticles Utilizing Yeast Cells
Gold nanoparticles (GNPs) have proven to be versatile technological tools, especially in the field of biomedicine. GNPs can be functionalized through different coatings for tasks like drug delivery, diagnostics, and biosensing. To further understand how GNPs can be altered for use as a biomedical tool, the cellular association of GNPs coated in different combinations of polyethylene glycol (PEG), sodium citrate, bovine serum albumin (BSA), and rabbit anti Saccharomyces Cerevisiae (antibody) with yeast cells was evaluated. This was tested through two main sample groups coated in either a base layer of sodium citrate or PEG. Each group had three samples that were tested, one only including the base coating, one including the base and BSA, and another including the base, BSA, and the antibody. Each sample was incubated with yeast and then analyzed through the use of a Nanosight.