Faculty Sponsor(s)
Brad Nolen and Andrew W. Baggett
Subject Area
Chemistry
Description
The primary objective of this research is synthesizing derivatives of known Arp2/3 inhibitor CK-666 and to determine their potency of inhibition of the Actin Related Protein (Arp 2/3) complex. A potent Arp2/3 inhibitor may be of interest in clinical anti-cancer and anti-tumor applications. Additionally, an Arp2/3 inhibitor with nanomolar potency could be used to advance basic actin dynamics research. Herein the organic synthetic efforts towards the 2-methyl-7-azaindole derivative of the known Arp2/3 inhibitor CK-666 are described. Polymerization assays providing preliminary in vitro IC50 data are also discussed.
Recommended Citation
Zhang, Tingting; Nolen, Brad; and Baggett, Andrew W., "Synthesis and Preliminary Bioactivity of Potential Inhibitors of Arp 2/3 Complex" (2024). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 32.
https://digitalcommons.linfield.edu/symposium/2024/all/32
Synthesis and Preliminary Bioactivity of Potential Inhibitors of Arp 2/3 Complex
The primary objective of this research is synthesizing derivatives of known Arp2/3 inhibitor CK-666 and to determine their potency of inhibition of the Actin Related Protein (Arp 2/3) complex. A potent Arp2/3 inhibitor may be of interest in clinical anti-cancer and anti-tumor applications. Additionally, an Arp2/3 inhibitor with nanomolar potency could be used to advance basic actin dynamics research. Herein the organic synthetic efforts towards the 2-methyl-7-azaindole derivative of the known Arp2/3 inhibitor CK-666 are described. Polymerization assays providing preliminary in vitro IC50 data are also discussed.
