Faculty Sponsor(s)
Andrew Baggett and Brad Nolen
Location
Jereld R. Nicholson Library: Grand Avenue
Subject Area
Chemistry
Description
The primary objective of this research is synthesize a derivative of 2-methyl-7-azaindole and to determine its potency of inhibition of the Actin Related Protein (Arp 2/3) complex. A potent Arp2/3 inhibitor may be of interest in clinical anti-cancer and anti-tumor applications. Additionally, an Arp2/3 inhibitor with nanomolar potency could be used to advance basic actin dynamics research. Herein the organic synthetic efforts towards the 2-methyl-7-azaindole derivative of the known Arp2/3 inhibitor CK-666 are described. Spectroscopy as it informs our continuing efforts to synthesize our target is discussed. Further synthesis plans are discussed as they relate to successfully reaching our target compound.
Recommended Citation
Zhang, Tingting; Baggett, Andrew W.; and Nolen, Brad, "Progress Towards Synthesis of Azaindole Derivatives of Arp2/3 Complex Inhibitor CK-666" (2022). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 3.
https://digitalcommons.linfield.edu/symposium/2022/all/3
Progress Towards Synthesis of Azaindole Derivatives of Arp2/3 Complex Inhibitor CK-666
Jereld R. Nicholson Library: Grand Avenue
The primary objective of this research is synthesize a derivative of 2-methyl-7-azaindole and to determine its potency of inhibition of the Actin Related Protein (Arp 2/3) complex. A potent Arp2/3 inhibitor may be of interest in clinical anti-cancer and anti-tumor applications. Additionally, an Arp2/3 inhibitor with nanomolar potency could be used to advance basic actin dynamics research. Herein the organic synthetic efforts towards the 2-methyl-7-azaindole derivative of the known Arp2/3 inhibitor CK-666 are described. Spectroscopy as it informs our continuing efforts to synthesize our target is discussed. Further synthesis plans are discussed as they relate to successfully reaching our target compound.
