Faculty Sponsor(s)
Brian Gilbert
Location
Jereld R. Nicholson Library: Grand Avenue
Subject Area
Chemistry
Description
Including environmental, industrial, and biomedical sciences, applications of gold nanoparticles are on the forefront of research in many areas. By altering the surface treatment of spherical gold nanoparticle cores, particularly those smaller than 100 nm (nanometers), one can influence their potential use in a number of ways. Lipid coated nanoparticles with specifically selected surface ligands can be used for multiple biomedical functions, including medical imaging, for use as colorimetric and plasmonic sensors within the body, and as cell or organelle specific targets for therapeutic drug delivery or cancer treatment. Here, spherical gold nanoparticles ranging in size from 8-40 nm (avg. diameter 23-48 nm) have been synthesized and coated with poly(allylamine hydrochloride) (PAH) and a mixed lipid solution of 1:1 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) and lysophosphatidylcholine (LPC), two of the four major types of lipids found in the human body. Characterization was performed using a NanoSight LM10HS particle sizer, and shows a gradual increase in size after each step in the coating process for nanoparticle cores ranging in size from 16-27 nm. The thickness of these purified and lipid coated nanoparticles was consistently 2-3 times that of the PAH coated sample it was layered onto, suggesting a successful, multi-layered coat that ranges in size based on the PAH coated core size. UV-Vis spectroscopy shows a slight red shift, indicating an increase in size and change in refractive index, which supports the presence of lipid coating on the PAH coated gold nanoparticle cores.
Recommended Citation
Wood, Victoria J.; Munjar, Christopher W.; and Gilbert, Brian D., "Lipid Coated Gold Nanoparticle Cores: Synthesis and Characterization" (2016). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 9.
https://digitalcommons.linfield.edu/symposium/2016/all/9
Lipid Coated Gold Nanoparticle Cores: Synthesis and Characterization
Jereld R. Nicholson Library: Grand Avenue
Including environmental, industrial, and biomedical sciences, applications of gold nanoparticles are on the forefront of research in many areas. By altering the surface treatment of spherical gold nanoparticle cores, particularly those smaller than 100 nm (nanometers), one can influence their potential use in a number of ways. Lipid coated nanoparticles with specifically selected surface ligands can be used for multiple biomedical functions, including medical imaging, for use as colorimetric and plasmonic sensors within the body, and as cell or organelle specific targets for therapeutic drug delivery or cancer treatment. Here, spherical gold nanoparticles ranging in size from 8-40 nm (avg. diameter 23-48 nm) have been synthesized and coated with poly(allylamine hydrochloride) (PAH) and a mixed lipid solution of 1:1 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) and lysophosphatidylcholine (LPC), two of the four major types of lipids found in the human body. Characterization was performed using a NanoSight LM10HS particle sizer, and shows a gradual increase in size after each step in the coating process for nanoparticle cores ranging in size from 16-27 nm. The thickness of these purified and lipid coated nanoparticles was consistently 2-3 times that of the PAH coated sample it was layered onto, suggesting a successful, multi-layered coat that ranges in size based on the PAH coated core size. UV-Vis spectroscopy shows a slight red shift, indicating an increase in size and change in refractive index, which supports the presence of lipid coating on the PAH coated gold nanoparticle cores.
