Student-Faculty Collaborative Research Grant Report
Analytical Chemistry | Chemistry | Materials Chemistry
Funds were requested to support one student to investigate the development of silica sol-gel based materials containing silver-nanoparticles (NP) as possible chemical sensors by observing surface enhanced Raman spectroscopic (SERS) changes in the spectrum of a target compound, 3,3’-dihexyloxacarbocyanine iodide. The organic fluorescent dye, 3,3’- dihexyloxacarbo-cyanine iodide (DiOC6(3)), was chosen as a target molecule for detecting distinguishable SERS signals and as a basis for Ultraviolet-Visible (UV/Vis) Spectroscopy in base-catalyzed and acid-catalyzed silver colloid sol-gels because of its facilitating ability to stain and identify mitochondrial changes during early apoptosis in animal and plant cells, and for its capability to stain and visualize thrombus formation in red blood samples.
Sean Webster was the lead student investigator on this project and worked closely with me to develop working protocols to carry out the investigation. This project builds upon my previous research involving the development of new host materials for chemically active probes that can be used as sensors. The goals of this project were twofold: 1) to develop new SERS actively labeled NP materials, and 2) to investigate the spectroscopic changes that can be detected by (SERS) in different environments that may lead to possible sensors or drug delivery applications.
Atkinson, Elizabeth, "Student-Faculty Collaborative Research Grant Report" (2021). Post-Grant Reports. Report. Submission 213.