Synthesis and Testing of Azaindole Inhibitors of Arp2/3 Complex
Biochemistry | Chemistry | Organic Chemistry
We worked towards designing new candidate molecules for synthesis in collaboration with Dr. Zoe Cournia at the Bioacademy of Athens. We provided her with some new molecule designs we are interested in—specifically “azaindole” molecules, meaning molecules incorporating a nitrogen as an important element in a particular molecular framework. We continue to exchange information and results that help move our synthesis project forward.
The two students on this project spent the majority of their time performing organic synthesis, which is the process of building relatively complex molecules from simpler molecular building blocks. Emily Tiedemann worked primarily on applying the synthesis techniques that had worked previously in our group on the “non-azaindole” family of molecules to the new “azaindole” family. She found that several of the reactions worked equally as well as before, but had to change the chemicals and approaches used to succeed in other synthesis attempts. Natalie Wade focused on scaling up an aspect of the routine synthesis we do in our lab with the goals of making our lab activities cheaper, safer, and more environmentally friendly. Both students synthesized many new molecules and analyzed them for purity using our department’s instrumentation.
Neither student got to a “final compound” stage during the summer 2019 period of work, meaning that we do not have biochemical activity results yet for the new molecules we are working towards. However, both students are very close to a final compound and will almost certainly have some interesting biochemistry results following a trip to Eugene during this spring semester, and hopefully those will be able to be presented for the first time at the Linfield College Student Symposium in May 2020.
Baggett, Andrew W., "Synthesis and Testing of Azaindole Inhibitors of Arp2/3 Complex" (2020). Post-Grant Reports. Report. Submission 194.