Faculty Publications

Publication Date



Cell and Developmental Biology | Cell Biology | Developmental Biology | Genetics and Genomics | Molecular Biology


Aberrant microRNA (miRNA) expression correlates with human diseases such as cardiac disorders and cancer. Treatment of such disorders using miRNA-targeted therapeutics requires a thorough understanding of miRNA regulation in vivo. A recent paper in Nature by Davis et al. expands our understanding of miRNA biogenesis and maturation, elucidating a mechanism by which extracellular signaling directs cell differentiation via posttranscriptional regulation of miRNA expression.

Document Type

Accepted Version


This article is the author-created version that incorporates referee comments. It is the accepted-for-publication version. The content of this version may be identical to the published version (the version of record) save for value-added elements provided by the publisher (e.g., copy editing, layout changes, or branding consistent with the rest of the publication).


This is the author’s version of a work that was accepted for publication in Developmental Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental Cell, volume 15, issue 2 (2008), doi:10.1016/j.devcel.2008.07.015.

Original Citation

Catherine A. Reinke & Richard W. Carthew
BMP signaling goes posttranscriptional in a microRNA sort of way.
Developmental Cell, 2008, volume 15, issue 2, pages 174-175



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