Cell and Developmental Biology | Cell Biology | Developmental Biology | Genetics and Genomics | Molecular Biology
Aberrant microRNA (miRNA) expression correlates with human diseases such as cardiac disorders and cancer. Treatment of such disorders using miRNA-targeted therapeutics requires a thorough understanding of miRNA regulation in vivo. A recent paper in Nature by Davis et al. expands our understanding of miRNA biogenesis and maturation, elucidating a mechanism by which extracellular signaling directs cell differentiation via posttranscriptional regulation of miRNA expression.
This is the author’s version of a work that was accepted for publication in Developmental Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Developmental Cell, volume 15, issue 2 (2008), doi:10.1016/j.devcel.2008.07.015.
Catherine A. Reinke & Richard W. Carthew
BMP signaling goes posttranscriptional in a microRNA sort of way.
Developmental Cell, 2008, volume 15, issue 2, pages 174-175
Reinke, Catherine A. and Carthew, Richard W., "BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way" (2008). Faculty Publications. Accepted Version. Submission 12.