The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.
Anne E. Kruchten & Mark A. McNiven
Dynamin as a mover and pincher during cell migration and invasion.
Journal of Cell Science, 2006, volume 119, issue 9, pages 1683-1690
Kruchten, Anne E. and McNiven, Mark A., "Dynamin as a Mover and Pincher during Cell Migration and Invasion" (2006). Faculty Publications. Published Version. Submission 5.