Faculty Sponsor(s)
Andrew Baggett
Subject Area
Chemistry
Description
Carbon-carbon bonds are one of the most common bonds in organic chemistry. Alkyl boron coupling has been heavily studied but there is a gap with Csp3-Csp3 bonds made with boron reagents. Csp3 bonds are extremely relevant to organic chemistry and organic synthesis. The goal of this project is to optimize a Csp3-Csp3 copper catalyzed homocoupling with a boron reagent and generalize the reaction. To develop this reaction the alkyl boron reagent was synthesized with a Grignard reaction and the copper catalyzed reductive oxidation was screened at different temperatures and the products were analyzed with NMR spectroscopy. Progress will be presented at the symposium.
Recommended Citation
Proctor, Kenni; Baggett, Andrew PhD; Khazaei, Dan; and Russel, Katie, "Development of Copper-Catalyzed Alkylboron Oxidative Homocoupling" (2025). Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement. Event. Submission 3.
https://digitalcommons.linfield.edu/symposium/2025/all/3
Development of Copper-Catalyzed Alkylboron Oxidative Homocoupling
Carbon-carbon bonds are one of the most common bonds in organic chemistry. Alkyl boron coupling has been heavily studied but there is a gap with Csp3-Csp3 bonds made with boron reagents. Csp3 bonds are extremely relevant to organic chemistry and organic synthesis. The goal of this project is to optimize a Csp3-Csp3 copper catalyzed homocoupling with a boron reagent and generalize the reaction. To develop this reaction the alkyl boron reagent was synthesized with a Grignard reaction and the copper catalyzed reductive oxidation was screened at different temperatures and the products were analyzed with NMR spectroscopy. Progress will be presented at the symposium.
